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Oral Melanotic Macule An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth

First synthesized in the 1990s, MT-2 is classified as a non-selective melanocortin receptor agonist, meaning it is structurally compatible with multiple receptor subtypes (MC1R, MC3R, MC4R, MC5R)

Apart from zidovudine used in the treatment of HIV infection, antimalarials, oestrogen, ketoconazole, clofazimine, and imatinib may mediate the development of oral mucosal melanin hyperpigmentation [12, 38]

Women : Improved frequency of satisfying sexual experiences and reduced sexual distress scores in premenopausal women with HSDD (2)