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NNMT inhibition increases adipose [S-adenosylmethionine (SAM)] and [Nicotinamide adenine dinucleotide (NAD+)] levels As youll discover later on in this article, theres a good reason why increased production of SAM and NAD+ within fat cells is beneficial

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Although methylfolate and methylcobalamin do work together within the methylation cycle, tolerating one does not guarantee youll tolerate the othereven though many healthcare professionals suggest otherwise

This avoids over-supplementation in patients who do not need a particular nutrient, and it also avoids the false reassurance of shotgun supplementation covering up an actual problem