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For instance, intake of a low amount of vitamin C was associated with increased oxidative stress 84 , while high levels of antioxidant (supraphysiological level) resulted in reductive stress, which is as destructive to cells as oxidative stress

However, systemic administration of lactate oxidase carries the risk of off-target H2O2 toxicity, underscoring the need for tumor-specific delivery systems to improve safety and therapeutic outcomes

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