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A study investigated the relationship between hepatic diseases and psychiatric symptoms, focusing on the prevalence and impact of mental health disorders in hospitalized cirrhosis patients in the United States from 2002 to 2014 and found that 37% of cirrhosis patients had a mental illness diagnosis, with prevalence rising from 22.6% in 2002 to 54.1% in 2014

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136 scRNA-seq has identified insulin-like growth factor 1 (IGF-1) and secreted phosphoprotein 1 (Spp1)-expressing microglia as key sources of the proinflammatory cytokines IL-1 and TNF