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Cancers 12(11):3203 Simmerman E et al

& Hamley, I

The Synergy of Dual-Pathway Stimulation The complementary mechanism works as follows: Sermorelin activates GHRH receptors, telling the pituitary gland when to release growth hormone Ipamorelin activates GHS receptors, amplifying how much growth hormone is released during each pulse Research on the interaction between GHRH and GHS pathways has demonstrated that combined stimulation produces GH responses that are greater than the sum of individual responses a phenomenon described as synergistic rather than merely additive (7)

The decreased ALDH activity was reported in MASLD patients and may indicate an impaired acetaldehyde detoxification and increase their sensitivity to alcohol associated toxicity 98