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Description

SETDB1 deficiency clearly promoted the acquisition of the TGF--induced mesenchymal phenotype but reduced the expression of E-cadherin in human alveolar epithelial cells by catalyzing the deposition of H3K9me3 on Snai1 , which inhibited the protein expression of Snai1, the main transcription factor that initiates the epithelial-mesenchymal transition (EMT)