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Cote ML, Liu M, Bonassi S, et al

We reasoned that using cell-specific IC50 doses of MTX would have overthrown any metabolic differences among cell lines

It is ubiquitously present in mammalian cells and plays a central role in redox balance, cellular detoxification processes, and maintenance of intracellular thiol status

(Source 2, 3) Some scientists and clinicians, especially in functional and longevity medicine, propose increasing glutathione levels, primarily through supplementation, to promote health and prevent disease with aging