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Description

Moreover, these metabolic changes observed in G12D and G12V SW48 cells show striking similarities to the consensus molecular subtype 3 (CMS3) of colorectal cancer types, which show an association between increased KRAS mutations and elevated metabolic signature of glutamine and nitrogen metabolism (Guinney et al, 2015)

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Thus, excessive CB1 activation with exogenous THC may lead to NMDAR hypofunction which in turn downregulates genes involved in synthesis, recycling and utilization of GSH in developing neurons, promoting oxidative stress