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Funding This review was supported by the Natural Science Foundation of China (81974377), 345 Talent Project of Shengjing Hospital (20222025), and Outstanding Scientific Fund of Shengjing Hospital

The liver clears it almost entirely through cytochrome P450 3A4 (CYP3A4), producing inactive pyridine metabolites that are excreted in urine [1]

Our results align with a previous study [91], which demonstrated that SM nanoformulation could improve liver histopathology regarding connective tissue deposition and cellular infiltrates