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Cytoskeleton 64 , 794807 (2007)

Interestingly, a significantly elevated risk of ACPA-positive RA was observed among current smokers exposed to silica, exceeding the expected risk when the separate effects of silica exposure and current smoking alone were considered [57]

Phototransduction, phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (RPE) and the oxidization of polyunsaturated fatty acids (PUFAs) in the retina leads to the chronic production of ROS (64)