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Similar results were observed in another phase 1 clinical trial study that used a different synthetic -syn mimicking epitope called AFFITOPE PD03A (NCT02267434)

in 1950 [72], and this led to the observation that an enzyme from the kidney catalyzes removal of the -glutamyl group from glutathione and the formation of a new -glutamyl bond with various acceptor amino acids, and thereby produces several types of -glutamyl amino acids