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A relatively new class of drugscalled sodium-glucose cotransporter-2 (SGLT2) inhibitorshave proven beneficial for both diabetic and non-diabetic CKD and appear poised to become a mainstay treatment

Nakayama Y, Watanabe R, Murakami K et al (2022) Differential efficacy of TNF inhibitors with or without the immunoglobulin fragment crystallizable (Fc) portion in rheumatoid arthritis: the ANSWER cohort study

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A fundamental feature of aging is a decline in mtDNA transcription and repair capacity which can lead to mitochondrial malfunction and set in motion a vicious cycle of enhanced ROS production (Desler et al., 2011)