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The four SCLAs were also senolytic against a wide range of senescent cells, including IMR90 cells treated with etoposide, MCF7 breast cancer cells treated with either etoposide or tozasertib and PC3 prostate cancer cells treated with palbociclib (Extended Data Fig

These studies suggest that deficiencies in GH and IGF-I contribute to a functional decline in senescent rats, whereas augmentation of GH or IGF-I improves cognitive function, increases glucose utilization throughout the brain, increases cortical vascularity, and ameliorates age-related decline in hippocampal neurogenesis