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Friedman RC, Farh KK, Burge CB, Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs

A basket study that implements multiple independent two-stage designs will have a much higher false-positive rate than a typical phase II study and therefore a higher likelihood of being declared effective in at least one basket when in fact the drug is truly ineffective [132]

Additionally, the review highlights morin hydrate as a promising adjuvant that enhances cisplatin efficacy in hepatocellular carcinoma while reducing its systemic toxicity