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554 Relatively modest manipulation of gene expression using normal alleles may be sufficient to mitigate the effects of deleterious mutations

MES28 GSCs expressing Flag-G3BP1 protein were treated with 5 Gy IR ( m ) or 200 M TMZ ( n ) for 1 h, and then purified Flag-G3BP1 from cell lysates using anti-Flag Abs-conjugated agarose, followed by elution from beads and analyzed by MALDI-TOF/TOF MS

The promises and pitfalls of epigenetic therapies in solid tumours