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2 Ferroptosis 2.1 Ferroptosis characteristics Ferroptosis causes cell membrane rupture and blistering, mitochondrial shrinkage, mitochondrial ridge decrease or removal, increased membrane density, and normal nuclear morphology, but there is no chromatin condensation, according to the ultrastructure of the cells

Documented observations within controlled laboratory research models Recorded observations in experimental models are primarily associated with glutathione-related redox signaling, oxidative stress markers, and intracellular antioxidant response behavior

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Then, depressive and manic symptoms, treatment acceptability, gastrointestinal and other side effects are assessed at baseline (prior to randomization) and weekly, whereas stool samples to evaluate microbiome composition are obtained at baseline and 3 and 6 months [332]