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dr david perlmutter glutathione MD, FACN Brain Defenders Webinar Dr. Episode #32: Autophagy and ATD with Dean David H. Perlmutter, MD John T. Milliken Department of Medicine Mark A. Perlmutter, M.D. New Jersey Urology Perlmutter Cancer Center Medical Oncologist Advances Treatments for Multiple Myeloma NYU Langone News

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However, excessive ROS accumulation can lead to oxidative damage, disrupting cellular components and ultimately triggering cell death [4]

Consistent with this, cells limit GSSG buildup through efficient recycling and export mechanisms 8

ROS generated during oxidative stress can activate the IB kinase (IKK) complex, which phosphorylates IB proteins and marks them for ubiquitin-mediated degradation