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Ever since B12 emerged in the 60s, when it was often mixed with amphetamines, and then later, when everyone from Madonna to Margaret Thatcher was trying it out, its efficacy has been the subject of debate

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Some risk factors for vitamin B12 deficiency include: Old age Atrophic gastritis (a condition that damages the stomach lining) Certain health conditions and medications A vegan or vegetarian diet How Do I Know If My Vitamin B12 Levels Are Low

A Cochrane review comparing oral and intramuscular B12 found comparable effects on blood levels, and the same principle of good absorption applies to the subcutaneous route