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Description

A family of histone deacetylases known as sirtuins (Sirt 1-7) controls a number of proteins involved in cellular metabolism, stress responses, circadian rhythms, and endocrine functions

Jones et al., 1984)

In the GLS2 filament structure, each tetramer interacts with its immediate neighbor through an interface of six alpha helices on the lateral side of the catalytic domain near the lid loop that closes over the substrate binding site (Fig