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After age 25, the body loses approximately 1% of its collagen per year, a rate that is slow enough to be invisible month-to-month, but rapid enough to produce visible changes in skin texture, wound recovery, and hair quality over a decade

In particular, the pivotal biochemical pathways (i.e., apoptosis and oxidative stress, mitochondrial impairment, dysfunctional mitophagy, unfolded protein stress, and improper removal of misfolded proteins) have been widely explored in cell lines, challenged with toxic insults or genetically modified

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It guides us toward safer, more ethical, and ultimately more successful scientific exploration