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doi: 10.1155/2012/329635 51 KuznetsovAVMargreiterRAmbergerASaksVGrimmM

Batooei M, Tahamoli-Roudsari A, Basiri Z, et al

Dev Cell 31(3):345-357, 2014

Because of its conserved structure in diverse pathogens of this kind, it is recognized as a pathogen-associated molecule (PAM) by many different receptors, such as toll-like receptor 4 (TLR4) on immune cells (e.g., monocytes, macrophages, neutrophils and dendritic cells), and it stimulates a robust inflammatory response by activation of caspase-4 and caspase-5 in humans and thence secretion of pro-inflammatory cytokines