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In a hyperglycemic environment, non-enzymatic glycation reactions are enhanced, leading to the formation of AGEs (83)

Such events include, but are not limited to 2 Sidari A, Hill E

Given that cancers may alter their metabolism in response to traditional chemotherapy and targeted agents, metabolic inhibitors such as inhibitors of glutamine metabolism are particularly attractive targets in synthetic lethality studies

The results of an experimental study revealed that methyl donor supplementation, in which folate and vitamin B12 were among them, could improve obesogenic diet-induced hepatic triglyceride accumulation in a sample of rats 27