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The AF is a concentric layered structure with 1525 layers mainly composed of collagen (COL) I and an outer layer composed of fibroblasts with neurovascular distribution [14]

Of these, the latter two hypotheses have been recently mathematically examined to have identical calcium-dependent dynamics which provides strong theoretical evidence for a calcium-based model of plasticity, which in a linear model where the total number of receptors are conserved looks like where is the synaptic weight of the th input axon, is the concentration of calcium, is a time constant dependent on the insertion and removal rates of neurotransmitter receptors, which is dependent on , and is also a function of the concentration of calcium that depends linearly on the number of receptors on the membrane of the neuron at some fixed point

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CRISPR-mediated functional engineering for hPS cell-based PD models Extending beyond CRISPRi, CRISPRa and epigenetic regulation, CRISPR technology has advanced toward functional engineering that reproduces pathogenic processes with spatial, temporal and quantitative control