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Moreover, by modulating the production of gut microbiota-derived metabolites (such as butyrate), AMPK indirectly influences liver lipid metabolism

Sasaki, A., Yamaguchi, H., Ogawa, A., Sugihara, S

The Austin Chronicle

Other afferent blood-borne molecules on the MGB axis include bacterial antigens (242) and inflammatory cytokines such as IL-6, IL-1 and TNF-, which may be produced in a context of gut inflammation