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doi: 10.1042/bj20090729

JTCVS Open 24:376-382, 2025

Activity-driven local ATP synthesis is required for synaptic function

Apart from the traditional targeted drugs that aim at inhibiting glutamine transporters and GLS, an increasing number of promising targets directly or indirectly involved in glutamine metabolic pathway have been studied, with the aims of achieving an antitumor effect by blocking the glutamine-dependent metabolism in tumor cells (61,93)