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As illustrated in Figure 1, genetically determined increased levels of TLR2 (rs1816702) and MD-2 ( LY96 ) (rs11465996) (required for TLR2 and TLR4 to respond to LPS) 15, 16 were associated with beneficial response among patients with CD, indicating that a higher activity of TLR2 was associated with a beneficial response among patients with CD