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OM, oral mucositis

Trends Biochem Sci (2019) 44(5):46777

10.1603/EC12089 13 ArandaJ.CerqueiraN

Phosphorylated JNK travels into the mitochondria to further phosphorylate many mitochondrial proteins, including the mitochondrial ETC, causing even more ROS leakage and oxidative stress by binding to SH3 homology associated BTK binding protein (Sab) [110, 275]