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For instance, microtubule glycoside A (TubA), a small molecule compound identified based on analyzing the protein crystal structure of ABCF1-K430la and screening for drugs, mainly targets ABCF1 lactylation to promote HCC cell growth and organoids, inhibiting HCC progression

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Walker and Burggren, 2020b), as well as more recently emphasized enhancers that can facilitate all of these actions (Wu et al., 2023)

J Cell Biol 215:823840 Kumar P, Wittmann T (2012) +TIPs: sxIPping along microtubule ends