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Pyroptosis by NLRP3/caspase-1/gasdermin-D pathway in synovial tissues of rheumatoid arthritis patients

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Furthermore, DAMPs such as calretinin significantly enhance macrophage phagocytic activity through eat me signals such as CD91, accelerating the clearance of apoptotic cells to maintain tissue homeostasis (Gardai et al., 2005) (194).This multimodal response mechanism enables macrophages to precisely regulate between immune defense and tissue repair based on the type and duration of DAMPs