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Despite the promising efficacy observed in Th- MYCN -derived 3D spheres, administration of the compounds resulted in gastrointestinal toxicity, including blocked intestine and stomach enlargement, necessitating early termination of the experiment

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This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

Implications of Regulatory Decisions on Prescription Practices Regulatory decisions concerning weight loss medications, particularly FDA approvals or denials, significantly impact clinical guidelines, prescribing practices, and the overall approach to obesity management in medical practice