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Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]

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Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB J Exp Med 1997 185 : 18971907 Esslinger CW, Jongeneel CV, MacDonald HR

A shared nearest neighbor (SNN) modularity optimization-based clustering algorithm and the Uniform Manifold Approximation and Projection (UMAP) algorithm were utilized to project all cells into two-dimensional coordinates for visualization