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The introduction of dietary modifications may lead to weight reduction and alleviate disease symptoms (220)

Despite a positive trend toward addressing underrepresentation and reporting sex-specific results, significant efforts are needed to develop and implement strategies that specifically improve female representation in RCTs

Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Reta initiation Weeks 1-4 Retatrutide 2 mg/week Cagrilintide Not started Notes Confirm retatrutide GI tolerance first

Each of the main types of injection (intravenous, intramuscular, intradermal and subcutaneous) have a number of disadvantages, which will help the healthcare professional choose the most appropriate injection technique to use based on the patient and type of product to administer