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Adiponectin: role in physiology and pathophysiology

doi: 10.1152/physrev.00041.2006 142 JuszczakGRStankiewiczAM

In addition, current evidence gaps exist due to lack of research stan-dardization in examining symptom clusters, incomplete research on herbal toxicity and safety, insufficient evidence for direct antitumor activity of herbs (relying mostly on pre-clinical data), few high-quality RCTs to validate their clinical efficacy, and studies in homogeneous populations (Asian) lacking generalizability [58]

Among these elements, ATF3 predominantly regulates the basal and stress-induced expression of ChaC1 through ATF/CRE, while ATF4 primarily regulates stress-induced ChaC1 expression through ATF/CRE and ACM (48)