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Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimers disease: metabolic basis for dementia

Listen to this episode in its entirety to learn more about the multitude of factors common and uncommon that contributed to Daves ill health, why Dave believes mitochondria are the key to slowing down the aging process, the sometimes misguided memory of the immune system and what we can do to point it in the right direction, why Dave puts butter in his coffee instead of milk or cream, the difference between real Bulletproof coffee and what the small-town cafe on the other side of the world is trying to peddle as Bulletproof coffee, the terrible thing Dave learned in business school about the value of a dollar, why getting stuck next to someone who bathed in olfactory-offending cologne can make you hangry (and what you can do to alleviate the problem), and much more

Li et al., 2021a)

Joseph, MI) 59,60 and reverse-phase ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS) (1,290 Infinity UPLC/6,550 iFunnel Q-TOF, Agilent Technologies, Santa Clara, CA) (DIALONG and PROLONG) in both positive and negative electrospray ionization mode 61