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These effects are not only dependent on mechanical load, because the skeletal muscle may serve as an endocrine organ that is capable of secreting cytokines to modulate bone metabolism [3, 4]

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The main function of SODs was to decompose superoxide radicals into molecular oxygen and hydrogen peroxide inside cells, which reaction is as follows: Based on the functional metal cofactors located at the active sites, four distinct classes of SODs have been found (Figure 1)