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In addition to T-brachyury, expression of Sonic hedgehog ( Shh ) and hepatocyte nuclear factor ( HNF )-3 (also known as FoxA2 ) is important for successful differentiation and survival of notochordal cells (Risbud and Shapiro, 2011)

Furthermore, TAK1 phosphorylates and activates several kinases, such as ERK, p38, JNK, AMPK, and IKK, which play a critical role in inducing autophagy in various settings [214]