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Neuroprotective effect of ashwagandha extract against the neurochemical changes induced in rat model of hypothyroidism

Platelet counts and concentrations of fasting blood sugar (FBS), hemoglobin A1c (HbA1c), immunoreactive insulin (IRI), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, non-esterified fatty acids (NEFA), aspartate aminotransferase (AST), ALT, -glutamyl transpeptidase, ferritin, and type IV collagen 7 were measured using standard laboratory techniques before and after glutathione treatment

In contrast, a GSSR intermediate was detected and its decreased steady-state concentration at higher glutaredoxin concentrations was suggested to support monothiol mechanism (i) 60