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People on vegan and vegetarian diets are at higher risk of glutathione deficiency, even with high consumption of sulfurous foods, due to low levels of Vitamin B12, which can only be derived from animal sources

Interestingly, a number of intracellular proteins that can be released and act as endogenous inflammatory signalling molecules (also known as damage-associated molecular patterns) can undergo glutathionylation, including high mobility group box 1 protein (HMGB-1) 14 , proteins of the S100 family 15 , galectin-1 16 , peroxiredoxin-2 (Prdx2) 17 and heat-shock protein 70 (HSP70) 18

Stoffels et al., 2017)

And its the only pine bark extract that is pharmaceutical GMP approved