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The NAC region, enriched in hydrophobic residues, possesses strong amyloidogenic properties and serves as the principal driver of -synuclein aggregation 44

To study the responses of the glutathione-related genes to the heavy metal stress at different time points, above A

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if the outer annulus fibrosus subsequently ruptures, the nucleus pulposus completely extrudes (non-contained herniation), potentially protruding into the spinal canal or lateral recess, compressing the cauda equina and nerve roots, causing pain or motor dysfunction (Figure 1)