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Tregs take up lactate via MCT1 (encoded by Slc16a1), convert it to pyruvate for entry into the TCA, and generate phosphoenolpyruvate (PEP) via PEP carboxykinase (PEPCK), which feeds back to promote gluconeogenesis and nucleotide synthesis to support Treg proliferation

Minekus M, Alminger M, Alvito P, Ballance S, Bohn T, Bourlieu C, Carrire F, Boutrou R, Corredig M, Dupont D, Dufour C, Egger L, Golding M, Karakaya S, Kirkhus B, Le Feunteun S, Lesmes U, MacIerzanka A, MacKie A et al (2014) A standardised static in vitro digestion method suitable for food-an international consensus

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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