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Faucheux, B

Figure 8 provides Ex-vivo (diffusion) release using porcine ear skin of a transdermal patch incorporating batch 11

AOP Development Strategy Context This AOP was developed for the project "CHRONIC TOXICITY OF PESTICIDES IN DRINKING WATER IN PARABA (TRIGGER): IDENTIFYING THE TRIGGERS OF A SILENT EPIDEMIC," financed by the "Fundao de Apoio Pesquisa do Estado da Paraba (FAPESQ-PB)." The project aims to understand how oxidative stress and reproductive toxicity can be triggered in animals by aquatic pollutants, such as atrazine Strategy The first step in developing this AOP was to conduct a literature review to gather toxicological data on the herbicide atrazine's impact on aquatic vertebrates in relation to oxidative stress and reproductive toxicity

Key Benefits: Protects cell membranes from oxidative damage Works synergistically with vitamin C May reduce cataract risk when combined with other antioxidants Supports overall retinal health Excellent Sources: Nuts and seeds: Almonds, sunflower seeds, hazelnuts Healthy oils: Wheat germ oil, sunflower oil, safflower oil Leafy greens: Spinach, Swiss chard Avocados: Rich in vitamin E and healthy fats that enhance absorption Daily Goal: The RDA for vitamin E is 15mg (22 IU) for adultsabout one ounce of sunflower seeds or almonds