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Acupuncture shows potential in ME/CFS management through its ability to activate the vagus nerve, reduce pro-inflammatory cytokines, polarize immune cells toward an anti-inflammatory state, and inhibit critical inflammatory signaling pathways [177, 178]

The activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) constitute a first-line antioxidant defense system that plays a key and fundamental role in the total defense mechanisms and strategies in biological systems 81

For instance, butyrate enhances astrocytic neurotrophic support, promoting slow-wave sleep and cognitive function [113,114,115,116]

& Gilroy, D