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Similar to cagrilintide, pramlintide is primarily eliminated via the kidneys and, in a pharmacokinetic study in participants with type 1 diabetes, no statistically significant differences were noted in total (AUC 0- ) and peak ( C max ) exposure after administration of a single pramlintide 60 g dose in participants with mild, moderate or severe renal impairment compared with those with normal renal function, although inter-patient variability was high [20]

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Consequently, due to known differences in risk for the development of DKD, treatment of youth with T2D with RAAS inhibitors may be more frequently indicated than treatment of youth with T1D

These sleep-enhancing peptides are generally administered subcutaneously