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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

As such, the maintenance of GSH and Prdx2 antioxidants are essential to protect the RBCs from these reactive oxygen species (ROS)

Interestingly, NAC exerts a GSH-supplementing effect in GSH-deficient cells, whereas this effect may be ineffective in GSH-enriched cells [101]

Quinn JF, Whittaker MR, Davis TP