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Required laboratory assessments include complete blood count (CBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), creatine kinase (CK), aldolase, antinuclear antibodies (ANA), rheumatoid factor (RF), and a full metabolic panel including liver and kidney function tests

It has also shown efficacy in managing conditions such as chronic fatigue syndrome, autism, and HIV/AIDS

Given widespread vitamin D deficiency, we suggest co-administration with the UL of 4000 IU vitamin D 3 daily with any folate therapy unless serum vitamin D is known to be above the 50 th percentile

Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klbl M, et al