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Dengler, R

Once all chromosomes are correctly aligned and attached, the inhibition by the SAC is relieved, facilitating the equitable distribution of chromatids to daughter cells (26)

4.6.8 Mitochondrial Function and Energy Metabolism Energy metabolism is dysregulated early in the course of ALS as a result of decreased appetite, increased energy expenditure, and hypothalamic dysfunction, among other complex factors [295,296,297,298,299]