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Accordingly, oxidative and nitrosative stress may contribute to the emergence of sleep disturbances, fueling a pathophysiological loop with neuroinflammation induced by these abnormalities

The authors argue that this result may be linked to allostatic load, given the long duration of the disorder in the patients evaluated (Hori et al., 2024)

Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability

A caspase activation and recruitment domain appears to contribute to the development of adipocyte hypertrophy, while caspase-1 is essential for the influx of macrophages into adipose tissue under HFD conditions (211)