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For ITT, mice were fasted for 6 h and intraperitoneally injected with insulin (0.75 U/kg body weight for NCD-fed mice or 1 U/kg body weight for HFD-fed mice)

Diazepam acts through the GABA system

Thus, chemotherapeutic approaches to blocking DNA replication through disruption of disulfide reductase pathways will need to be cognizant of the potentially complete functional redundancy of the GSH and Trx pathways in animal systems, and sensitive to the various other physiological roles these pathways play in normal homeostatic and stress-response pathways