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Growing evidence indicates that ferroptosis is a crucial factor in the development of neurodegenerative conditions like Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinsons disease (PD) [14, 111]

39 Besides causing tissue injury, ROS can also activate the NF-kB pathway to amplify inflammation through upregulation of expression of multiple genes, such as IL-6, TNF-, and chemokines