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Isomalt has a minimal cooling effect -positive heat of solution-, lower than many other sugar alcohols, in particular, xylitol and erythritol

This association effect is modified by genetics, such that HIV neuropathy patients with the single nucleotide polymorphism (SNP), a gene alteration in a single nucleotide, at allele rs28445017*A were significantly more likely to have a higher pain intensity than those with the SNP allele rs28445017*G 14

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In a recent study conducted in the pediatric age group, it was reported that no significant difference was observed in thiol-disulfide homeostasis and IMA levels between the MDD and control groups (21)